The San Francisco 49ers enter Sunday’s NFC West clash against the Arizona Cardinals at Levi’s Stadium (1:05 PM PT, FOX) navigating significant injuries along the defensive front. Pass rusher Nick Bosa was ruled out after injuring his calf during Thursday warmups—a setback head coach Kyle Shanahan estimated could keep him out “around a few weeks” as the team evaluates an Injured Reserve stint. With Bosa sidelined alongside Romello Height, Demarcus Robinson, and James Thompson Jr., San Francisco’s pass rush faces an immediate depth test against Jacoby Brissett and the visiting Cardinals.

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